I tried to maximise the USB potential with the following chain:
Matrix X-Fi PCIe USB card powered by iFi iPower external power plugged into my Furutech eTP-80 power board -> iFi Mercury 3.0 cable -> iFi Nano Galvanic 3.0 -> Furutech GT2 USB cable -> AGD Amanero USB. Sounded pretty clean, no ground loop, no more AC noise through my tube amps. I have a dedicated power pull from the DB for my audio stuff, switch-less Furutech NCF-50 wall socket, NCF filters on Furutech power cables and the abovementioned power board.
Then I went and bought the Singxer SU-6 and hooked up my Master-11 Singularity via RJ45 I2S and my R2R-R1 via HDMI I2S. I left the USB chain feeding the Singxer the same. Cables: The Chord Company C-Stream CAT7 cable (0.75m), and Wireworld Ultraviolet 7 HDMI cable (0.6m).
With the change to I2S, audio background is darker than my maxed USB setup, the sound dynamics have more heft and punch to them, very clean and lovely smooth sound from both DACs.
Would heartily recommend everyone interested in this to switch to I2S if you are able to.
I'll try sharing this here just in case it gives anyone some ideas xD
I use the Uptone ISO Regen before the Amanero USB, the Amanero board has the i2s isolator but without the builtin psu, so its usb powered. I use the Uptone Ultracap LPS to supply power to both the iso regen and the amanero board. Then the dac and amp are on a topaz line noise isolator. So the usb to i2s stage is completely isolated from the pc and ac mains, and the dac and amp are isolated from the usb stage and the ac mains. I can't think of a better way to set up at this point and I'm really happy with the sound. Impossibly clean, detailed, and non fatiguing.