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Why not go through every setting used.
If you don't know how to use the plugin, just don't use it... It took me months to set it up perfectly to my ears and now I feel like walking in heaven when listening. Absolutely natural sound with balanced sound layers (that means you will definitely loose some amount of detail in order to get a proper simulation of environment around you)
It is also good to mention that I don't like TB Isone as much as Isone Pro (previous version of this software). So I can only definitely recommend trying Isone Pro.
Why not go through every setting used.