I have now had the Isone plug-in in my rig for three days. During that time, I added a Decware ZSTAGE, so I had to re-listen to some things. While I appreciate the significant programming expertise in the plug-in, and its amazing flexibility, at the end of the day, I chose to disable it, and keep it disabled. The most significant reason is because the plug-in seems to "flatten" a lot of music, removing its third dimension. I know that sounds counter-intuitive, considering what the plug-in is designed to do, but while it can create an illusion of sound being projected from a distance away, that sound appears flat, like it is being "listened to on a wall," the way a video image might be projected on a wall. No matter what presets or settings I tried, the Isone sounded unnatural and always became fatiguing. I also never achieved any illusion that I was listening to good speakers. One benefit of the Isone though, and for which I will likely continue to enable it on occasion, is that some of the more extreme settings make good "teaching tools," helping you to exaggerate effects and listen for their impacts on the sound. That's not all bad. I could see it being useful for helping people to understand imaging and soundstage, at least in two dimensions. YMMV, so if you're interested, try it out. I am glad I did.
Another significant factor in favor of disabling the Isone plug-in is that Lucid mode on the Taboo is simply better. It is a better cross-feed approach in my experience. Not as flexible, since it can only be turned on or off, but simpler, more natural, and better. Truly three-dimensional.