I've been experimenting with swapping USB filters in and out between my Mac mini (running macOS/Windows) and the iDSD Signature.
I tried out the following:
1. iSilencer 3.0
2. iDefender 3.0 (with and without iPower X 5v)
3. iGalvanic 3.0 Nano
4. iUSB 3.0 Nano (which my Mac couldn't "see" so it was a bust)
5. Holo Audio Titanis USB Turbo filter
For me, an effective USB filter makes the music sound a bit louder (due to a reduction in background noise) and a little crisper/clearer. None of the devices I tried were able to achieve that. The only sound changes I detected were a slight rounding of treble and a slight softening of transients. Not a desirable outcome. The iDSD Signature sounded best with a direct USB connection to my Mac.
Conclusion: iFi did well with its USB implementation in the iDSD Signature. Just like with the iDSD Pro, none of my USB filters were able to improve upon the iDSD Signature's sound.
I just repeated the USB filter test described above with the Signature on firmware 5.2. It's after midnight, and I thought maybe at night when things were quieter, I might hear more of a difference by trying different combinations of USB filters. No such luck. There was no noticeable difference.
However, I thought to switch out the crappy 77-cent C7 power cable that came with my Mac Mini for a more solidly-built model and that got me some results. The music sounded louder and I could pick out different instruments in the mix more easily. For example, when listening to the MFSL version of Tears for Fears' "Songs From the Big Chair," the sound was less compressed. I could hear the overlapping lines of bass, guitar, and percussion on "Mothers Talk" more separately and distinctly.
Then I thought, "There's an improvement! Now I'll be able to hear the difference with the USB filters". So I tried the filter test again.
None of the filters noticeably changed the sound.
I did find that after trying all of the filters twice, when using the Signature's bit-perfect filter, a USB filter would smooth over poorly-recorded music so it's more tolerable. But once you switch to the minimum-phase filter, the difference is negligible. The minimum-phase filter by itself will smooth over poorly-recorded music.
This was a disappointing evening (especially for my sad collection of filters), but I'm glad I don't need to use a box in-between my Mac Mini and the Signature.
EDIT: Well, it's 3 AM, so why not try something else? I plugged my Mac Mini and its powered docking station into a battery-powered sine wave power regenerator (I have one for power outages). Wow! A huge difference in the sound. So much cleaner and less "edgy" and I can hear more at lower volumes.
Lesson learned: Upgrading my source's power cable/supply made a much bigger difference than trying to improve the USB connection between the Mac Mini and the Signature.