I would love to argue a lot, but I can't as my obvious problem is not er4 amped or not, but fuze or not ^_^.
I've owned and will own some sansas for as long as they are produced, but I use them for convenience not as my main dap (and never did).
I can understand how it's a good combo as fuze and er4 have somehow the same kind of specifics. and that is, giving a rather small image of dimensions and volumes.
the er4 pinpoints the instruments in its so unique way, but the reverse effect is that each instrument occupies a very small space. the positioning is also a lot on the sides, variations are mostly in wideness and don't play as much as others in height and depth (I'm not arguing about who's right here).
and then a sansa will simply present a small space (call that intimate). all my other daps give more space to the imaging, sometimes at the cost of other things, but the general idea is here.
now everybody has its own tastes. when I do love a good sens of depth, and really don't care for width, usually people are happy and call a soundstage huge as long as it goes far on the sides.
all this to say that for people looking for more "dimensions" to the sound, an amp is usually the way to go with er4, but not much with a fuze as the line out suffers from the same symptoms ^_^. (that's why I always say bad things of the fuze and always say at the same time that the clip is great)
and then most amps add a little warmth (and some bass) to the sound that could be nice on the er4 to most people.but I can't say if it's because of a better driving power or just a coloration of the signature.
I also usually felt that it mades the er4 behave better on symphony with loads of instruments, but I wouldn't swear that it's not just in my head for this one.
lastly I can give my own odd favorite experience with an er4. it's been with a RSA protector going with the "almost balanced" thing it does. that amp has a lot of limitations (it's super warm, not resolving at all, cuts the bass too soon, has no shielding against smartphones etc...) but the result with the er4 (they are some kind of opposites) was my single favorite memory of an er4. a nice 3D bubble-like positioning of the instruments. again don't get me wrong, I don't believe that to be the "right way" to present sounds on a headphone, but the most enjoyable for me, certainly.
so I'm all with the idea that amps can better your er4. but probably not much with a fuze so I agree with everybody \o/