Hey guys. I just wanted some input and this seemed like the most recent thread. I just yesterday got a pair of HD650s. I've used them to listen to music for about, eh, 10 hours since then, and I played pink noise while I slept last night, about 6 hours. I have a DAC/AMP combo NuForce Icon-2.
I find that there is like anemic, totally underwhelming bass. Bass guitars are audible, but not present. I can hear notes but not, you know, say that it has any presence. (I'm not expecting the bass oomph of speakers.)
OTOH, drums are insanely detailed. Holy crap. I wish I were a drummer, because I feel like I'm learning a lot about songs I used to think I knew. Instrument separation is great, in general, but when music gets busy/loud it gets a little muddy. (I'm listening to a bunch of ALACs of MSFL recordings.)
Listening to the HD650s from my iPhone 4, they sound about the same as through the Icon-2. The Icon-2 may round out/expand the sound a bit, but the iPhone 4 doesn't seem to drive them poorly. My only point of reference is an old pair of Alessandro MS1s, which don't seem to gain from the amp, but I think the DAC aspect makes separation a little more pronounced.