I own the E5 and have used it with my Beyerdynamic DT 990 Premium (32 Ohm) and Sennheiser HD 650 -- sorry, no M50. It has excellent fidelity (in my opinion.)
It's been great for music. It won't always go as loud as I want for some Blu-Ray discs when attached to my BD player. And, I don't ever crank the volume to deafening levels ... except to see what it will do.
Its major limitations are its limited gain and a tendency to clip when, with a hot source, its volume control is set high.
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