I was having the issue with the channels randomly swapping.
I tried creating a fresh Windows 8.1 x64 install - same thing happened.
I tried using the 16 drivers as opposed to the 22. And this helped some, the issue occurred less frequently -- but I noticed that there was something funny going on with the SBX surround. Sounded muddy, sounded like I was getting surround effects even when SBX was off.
I had seen that some users had their issue resolved by placing their card in a pcie 1x slot.
On my motherboard (Gigabyte P67a-ud7-b3) the lone PCIe 1x slot had a gigantic heat sink behind it covering the NF200, not allowing any card longer than the pcie 1x slot.
So I broke the heatpipes on each side and removed the top part of that heat sink so just the base is on.
That NF200 is getting pretty hot... but it's totally screw*n worth it now. This ZXR is the t*ts! My gawd... I can't believe I was just going to be satisfied with the channels coming out of the right driver. This card has blown me away.
And I was able to go back to my old image so I didn't have to go through and reload all the programs.
I ordered a higher end low profile heat sink. Hopefully it gets here before my board melts