Alright, since we're talking about comparing USB on the DAVE, I have experiences of my own to share:
Today, I connected my 10 year old "once-considered-gaming-enthusiast" PC with a 12,5m optical cable to my Chord DAVE, as I wanted to compare it to my existing USB chain with a 12m Supra USB cable. The cables are that long due to the PC sitting in an office adjacent to the listening room. The USB chain remained connected to the Chord DAVE during the optical listening test, as it would be a hassle to take it out for each comparison, so you may consider the optical chain slightly handicapped in that regard.
The optical chain is:
PC -> 12,5m optical cable -> Chord DAVE
The USB chain is:
PC -> 12m Supra USB cable -> ISO REGEN (powered by LPS-1.2 connected via a male/male DC adapter) -> USPCB -> Chord DAVE
As I previously had confirmed that the PC -> Chord DAVE setup was capable of handling 192 KHz content using a much shorter 2m optical cable, I started listening to the optical chain using a 192 KHz recording from 2L, and it sounded absolutely great! I closed my eyes and let the music take me. Afterwards, I switched to the USB chain and while the same track still sounded very good, the microdynamics had been smoothed out a bit, causing a small drop of perceived clarity and reducing my emotional engagement with the music. Switching back to the optical chain restored that. The slight smoothing was now gone, leading to the orchestra and in particular the soloist violin being more clear, more dynamic, more engaging. I could close my eyes again.
I know my PC is very noisy as it is a watercooled monster with dual graphics cards, tons of fans, water pumps, etc. and the main reason I invested in the ISO REGEN/LPS-1.2 combo in the first place. I would think the problem area is either the small DC adapter or the lack of ferrites on the very long Supra USB cable, which is probably an excellent RF "magnet" due to its length. Since I hardly have any recordings in higher resolution than 192 KHz, I could probably settle for the optical chain, but the perfectionist in me would hate to leave the job half done. not to mention having expensive USB gear sitting around unused.
Has anyone experienced or had any luck getting rid of a slight smoothing over of microdetails in their USB chain by either getting rid of RF using ferrites on the USB cable or improving the DC connection to their USB source, e.g. ISO REGEN, micro- or ultraRendu or similar?