Just wanted to give some praise for these. I just got a pair from Guitar Center at the same price they're everywhere else and they are just amazing. Of course, I'm not an audiophile that buys headphones for hundreds of dollars, my best headphones so far had been the Grado SR60 many years ago and I blew one side pretty quickly. These remind me of them, perhaps those with more experience with many more headphones can say which of them is better, but these are a dream.
My previous headphones were the JVC HA-RX700, which are very good, but they require some EQ to squeeze their potential. Then I got the JVC HA-RX900, which turned out to be incredibly bad, so I sent them back and got the ATH-M40x today. From the first moment at the store, just connected to my phone with Poweramp, I could tell they were something else, so much that for the JVC I had the treble at the max and the EQ had the high bands also a bit above 0. As soon as I plugged these in with the same song, the treble was overwhelming, so I had to lower the treble knob and the EQ to almost flat. In fact, as far as the phone with Poweramp goes, the flat EQ provided pretty good sound with these.
When I came home and connected them to my Pioneer receiver, playing from the computer with iTunes and an M-Audio M-Track Plus as the sound output, going by digital coaxial to the receiver, I could tell the difference was also huge with the Pioneers. The same thing that required a V shaped EQ curve with the JVCs, I can get with an almost flat curve, at least as far as the iTunes equalizer goes. However, the sound also has more definition. I'm not a sound engineer so I don't know the technical terms, but it feels more real. In fact, one of the first songs I listened to was Gorillaz's "Feel Good Inc" and I noticed a guitar line on the right channel that I had never noticed before with any other headphones.
Of course they won't shine with every single song, if the song was poorly recorded it will still not sound great, just better. For example I'm a Queens of the Stone Age fan, but their latest record sounds like crap. In contrast, I wasn't at all a fan of Justin Timberlake, even to the previous album, but that guy made a huge improvement musically, and his latest album is not only great, it sounds excellent for the most part. And that's a joy to listen to with any decent headphones, but it shines especially with the ATH-M40x. 80's music is hit and miss, since some of it was recorded with excellent sound (Earth, Wind & Fire's "Raise" is a great example) and some absolutely horrible, like Stevie Wonder's "In Square Circle" although there are far worse ones that don't come to mind now. Duran Duran had some terrible sounding albums, although "Notorious" improved their sound a lot.
One thing I don't understand is that many people say they are flat and boring. Believe me, I've listened to many cans that were flat and boring, these most definitely are not. On flat headphones, you need a really V shaped EQ curve to get something similar to these, but you don't get the great sound quality.
They are fairly comfortable as well, once you adjust them right. They don't seem at the beginning the first time you put them on, but once you adjust them well, they are. They close really tight, when I put them on they're like those noise cancelling headphones, without being that kind of headphones. However, they don't get uncomfortable after a while, I've had them on for hours and I don't experience any discomfort.
The plug into the headset is really cool, you get both straight and coiled cables, and plug the one that you want. I don't like coiled cables, but perhaps for some situations I would like to have it.
I don't know how much better the M50s are, how much better they can be, because these are amazing. Besides, the M50x are $170, while these are $100. The M50xs would have to be a lot better for me to consider spending an extra $70 on them.
And while I was at the store (Guitar Center) I asked the guy if I could listen to the Sony 7506, to see what the hype was about, and they are fine, but the M40x are way better. The Sony's would need additional EQ to get to the response of the M40x.
So if you're looking for a really good pair of headphones but don't want to blow the bank account, these are a sure bet.