It is not "only a USB interface". It has galvanic isolation for one, that alone could give massive sound improvement. It also isolate EMI/RFI, significantly lowers jitter and has linear power supply built-in. Sonically, Eitr trumps most USB -> SPDIF converters out there, even the $1000 Mutec MC-3+. You can see the comparison
here.
I also have another USB decrapifier (iFi iPurifier2) that supposedly cleans the USB signal, but I barely hear any difference in sound quality if any. But with Eitr (only Eitr and R2R-11 in the chain), its massive and very apparent, especially the bass. It has way more bass quantity and impact. Sound layering and separation also improves a ton too. But the best thing about the SQ improvement is the vocals, all sibilance is gone, no digital shrill no more.
My friend had 2 Wyrds before, and it barely makes an improvement to F-1 + Intona, so he sold them. With I2S he thought Singxer SU-1 sounded the best for his DAC (Spring KTE L3) so I assume it might be the same for R2R-7. In the aforementioned blog post above, the poster said for coax, Eitr is better than SU-1 so it went with it for the R2R-11. Also Eitr is the cheapest of the lot, its no brainer. I use a
cheap $25 coax cable, but I think Schiit's $20 PYST coax cable should sound the same. Some people said on another forum that Audioquest Diamond/Coffee sounds better than Schiit PYST cable for the Eitr, but for 0.75m the Diamond costs $500, lets not go that path shall we.
EDIT: The PYST RCA cable is not 75 ohm, Schiit doesn't even recommend it for Eitr use. Some other posters are recommending Blue Jeans cables instead.
@FredA I'm tagging you, I thought you might want to know this.