On the topic of USB:
If you are not running a dedicated audiophile grade USB Card like SOTM or JCAT or PPA, you need to know that certain USB ports(depending on Motherboard design) on your computer is actually running off a "shared hub".
It could be very well that your USB Mouse or Keyboard or USB Harddrive is runnning on the same hub as your USB DAC. This is because ideally you don't want your mouse movements to "interrupt" the data transmission to your dac. Also certain USB Ports are nosier than others, try experimenting plugging to different USB ports to find out which one sounds best.
Another important "audiophile" tweak is to disable all sorts of USB Power Savings(If you are not running a laptop).
google for these two to learn how:
how to disable usb selective suspend
how to disable usb root hub power management
Worth reading and more information:
http://www.thewelltemperedcomputer.com/HW/USB_Trouble.htm
Also if you want the best sound out of your PC, you have to:
Set PC power plan to "High Performance"
Disable Intel SpeedStep(EIST) & Turbo Boost and Hyperthreading
Adjust EMI Spread spectrum in your BIOS
Use processor graphics for Display instead of High Powered GPU.
Pretty advance tweak, recommended only if your PC is dedicated for audiophile usage:
Google for: Cad windows 8 audio optimization