After doing a little digging, it turns out that the maximum plate voltage for the 6N12S is 300V (typically, plus or minus 10%).
You might find this document interesting. The 6N12S is listed on page 37.
https://www.govinfo.gov/content/pkg...VPUB-C13-6925b02fb6dcaa88935be001eb551b4c.pdf
And I have no idea what the number 500 represents in the data sheet
@triod750 posted.
Recently I measured B+ in my Glenn OTL with six 6N12S and found the value to be 320V. What this tells me is six of these tubes is fine, but running two or four is not a good idea. As the number of tubes in the output goes down, B+ goes up. And since the value is at max for six, I would not recommend less than that.