You ask some difficult to answer questions so you get a long slightly off-topic answer haha.
I have not done a blind test but I am not sure I would pass it. I very quickly get switching fatigue and everything sounds the same. The brain quickly adapts to a given standard so I feel like the most honest impression happens the first few songs after switching from a setup you've been using a while.
While visually switching from 4k 120hz to a 720p 60hz screen is jarring and horrible, I've found the brain is much more forgiving when switching audio gear.
Often if i'm visiting my parents and i've been listening to the RME for a weekend (it's so nice and portable!) I miss nothing in the sound, it sounds great. I've often thought: is my big stack at home really better than this? Then the moment I'm home again and put on the first song I get a big smile on my face.
The main difference for me between HM1 and the RME amp is that the HM1 makes me want to keep listening. It makes me head-bang, toe tap and air strum and everything sounds good, correct and not fatiguing.
The Zen Can certainly doesn't sound 10 times less. The Zen Can is a great little amplifier, but I wanted the best and according to a lot of trusted ears the HM1 was it. Cost me a year worth of savings but it brings me joy every day