I had this exact same issue that lasted a few weeks, I would get scared using the sound card, it seems as if its sending a high pitched screech at full gain 600 ohm regardless of what gain setting you put on. Once it happens it just ruins any activity your doing like listening to music, Id end up throwing my headphones on the floor for fear of going deaf.
I solved the issue, it is related to system interrupts, when a device such as a network adapter or your sound card wants resources it sends a hardware signal to the processor that stops running processes and takes priority. Each device has a IRQ (
interrupt request) associated to it.
I ran DPC Latency Checker which shows what is interrupting the system for resources and saw that I kept getting small peaks of high latency, when these spikes occurred the screeching would happen.
The first thing to do is to disable core parking in windows,
"
Core Parking" dynamically disables CPU cores in an effort to conserve power when idle. Disabled cores are re-enabled as the CPU load increases once again." When cores are parked it caused massive interrupt requests which raised latency.
I then disabled all unnecessary devices I don't need like Virtual Machine Network adapters, Wireless Adapters, On board sound in the BIOS, Disabled Intel speed-step in the BIOS which dynamically changes the CPU frequency, Disable Intel turbo boost in the BIOS, Disable C states in the BIOS.
In the latter before doing this I was getting frequent spikes of 4000 US latency, Now it stays under 50 US at all times, I've been using the sound card for months now with no more screeching.
If you are over-clocking your system set it back to stock as it causes system instability with detrimental performance on system interrupts. Think about it your sound card demands resources from your computer, other devices are taking priority, you sound card is left stranded and screeches.
Also get the UNI Xonar drivers as they provide lower DPC latency!
Hope this helps