The memory wire on the SE535 for me was really a joke.
Main problem making them uncomfortable is the thickness and diameter.
The factory cable material is already thick enough and the memory wire + cover adds even more thickness.
I'd say the memory wire is too stiff too. Connectors are loose so the cable spins too freely.
The total thickness of the cable + memory wire + cover makes them annoying for a start, and the total size is too much compared to the size of the SE535 housing and weight. This and the stiff memory wire causes unnecessary stress in your ears (and to the MMCX connector too) when you just wind it around your ears. Also depending on your inner ear shape, if the SE535 housing relaxes rather deep, the thick cable may cause fitting issues too (it did in my case, pain on the ear entrance).
Over time, the thick cable + memory wire + cover + free spinning cable can cause bad connection on the MMCX connector too. I also noticed bad connection on the end of the memory wire (opposite end from the connector) for a sec hand cable, probably caused by the stiffness.
It's a really good IEM if Shure didn't go too far with making the cable chunky and war-ready.
Removable is good but I didn't mind a thin cable and strain relief too.
I'm happy with the Pearl V2 cable on ebay. It's so stress free in every aspect.