Hi
@TheLastZealot &
@Xyrium,
Overall, there is nothing wrong with using the headout of any amp, especially USB interfaces, eg Focusrite Scarlett Series, Presonus Audiobox 22, to send the audio signal to a dedicated head amp as what
@Xyrium is referring to or describing doesn't really make sense unless your orginal source is terrible in the first place as all a head amp does is ampify the base audio signal.
For example, in my own setup, I have several head amps connected to my Lexicon Alpha's head out via a splitter (only onem the RNHP, is considered a high powered amp & I did upgrade the power supply which makes it even more powerful but I digress) as well as another head amp, Presonus HP 4, which is connected via a monitor controller, Drawmer MC 2.1.
In this case, I also use the pass through on the HP 4 to send the audio signal to a another amp for passive speakers.
I have been using this setup for at least 3 years with no issues & regarding the interface head out to head amps for nearly 20 years.
In other words,
@TheLastZealot, as long as your original audio signal isn't being overpowered or underpowered from an amp which doesn't have dedicated preout, eg head out direct to speakers or direct to &/amp for speakers, generally you should be okay or as the overall audio signal should be fairly stable throughout.
Hope this makes sense.
Hope you have a great day !