I've gone back and fourth for quite some time listening to both the HD650's and HE400's with my Schiit Magni and Modi stack. I thought both sounded equally good with different genre's, the HE400's with more bass heavy stuff (EDM, some hip hop) and the HD650's with more vocal music (some hip hop, rock, blues)
After upgrading from the Magni to the Asgard 2 I'm finding a bigger difference in the sound quality between the HE400 and HD650's. The HD650's sound far more smooth then before and the high frequencies on the HE400 sound a lot more hollow. The HE400 already has a very harsh treble before eq'ing (something they are known well for) but the whole upper frequencies have now started to sound far less involving then the HD650 with the Asgard. The bass punch is still harder on the HE400's, but I feel like the Asgard puts the HD650's up another level above the HE400 now. The sound stage, seperation, clarity, and overall smoothness of the entire presentation is really exceeding the HE400 now. Even the bass sounds better to me, more detailed and bit less boomy.
I can see how people say the HD650 is one of the best scaling headphones out there, I definitely feel like it's a league above the HE400's now.