By design, 12AU7 / 12AT7 / 12AX7 can be run in either 6.3 volt mode or 12.6 volt mode In the Lyr, one could use adapters such as these:
http://www.ebay.com/itm/Two-adapters-for-12AU7-ECC82-to-instead-6CG7-6AQ8-ECC88-TUBES-amplifier-/261667818185?
This adapter realigns the pins of a 12AU7 to work in a 6DJ8 socket and configures the tube for 6.3 volt heaters.
That said, given that the Lyr was designed around 6DJ8, a pair of 12AU7 may not sound very good. On the other hand, ECC85 / 6AQ8 is not much different than 12AU7, and these have been reported to sound quite good.
In my opinion, unless someone is feeling very adventurous, I would not recommend spending a significant amount of money to purchase a pair of 12AU7 plus adapters. On the other hand, if someone has a couple of these, or 12AT7 or 12AX7, the adapters don't cost all that much and it might be fun.
NB: As many in this forum know, I am always pushing the envelope when it comes to tubes. So it might be best to ignore this post lol.