Have you gone around auditioning speakers to figure out what you like yet? That, and the room variable, are the hardest parts - sadly we can't do speakers like headphones, buying dozens and selling efficiently after getting a handle on their sound
The amps are bigger and heavier too!
I latched onto Tannoy early and that's been great - kept upgrades relatively linear, and keeps me sane
But there's been others I've heard and liked a lot - Magico S5, Focal Sopra 3, Von Schweikert VR55 Aktive, and most recently the Acora Acoustics granite speakers. Really liked the Acoras with VAC gear. But at the end of the day, I'm always happy to go back home!