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Wow...I'm not any further along than I was when I started this thread! What I really want when I upgrade is the HD650 bass and space with more clarity and 'engagement' - but I need something that will get me there WHILE improving the HD650s.
In my experience, no amp has ever significantly changed the characteristic of a headphone. True to say that, disregarding your recordings, the amp is has the second biggest effect on the sound of your setup next to the headphones themselves, but it is unrealistic to expect a night and day difference. When you think about it, the sound of a headphone is, above all, determined by the design of the driver. Given a perfectly neutral amp, that is it has perfect dynamics, a perfectly flat frequency response, and can supply infinite power, the headphone would give you its intrinsic sound. Whatever amp the manufacturer use to test and create the headphone is probably the closest an amp will get to what this. People here love to say a better amp will help you unlock the full potential of your headphone. To me that sounds like it means an amp should strive as much as possible to be the amp mentioned above. Under that definition, a bad amp must be one that is in all aspects, deviated from this perfect amp.
If you're expecting a new amp to completely rewrite what an HD 650 sounds like, exactly how much does it have to be messing with the signal. I wouldn't call an amp that changes the signal that much a good amp at all. Be weary of what some people here would tell you is a "better" amp. To say an amp colours the sound is to say that the amp does not have an ideal frequency response. If this is your idea of "improving" the HD 650 it means you do not like the intrinsic sound of the HD 650 and you would be better served by using an equalizer or buying a different headphone. If what you want to change is the dynamics of the HD 650, such as timbre, detail separation, or space, a closer to ideal amp may help. Most people would call an amp like this neutral.
My experience with the HD 650 follows the second path. Most, at least the ones I've liked, more expensive amps have only incrementally improved the dynamics. No amp I have ever tried has significantly made it sound "like a different animal". I do not doubt amps have different frequency responses, I only doubt people's ability to accurately describe the magnitude of those differences.