I have a pair of the IRIS headphones from their Indiegogo campaign, and they do indeed have excellent isolation even with glasses--better than my Oppo PM-3 headphones, which have good isolation. I tried them out against my Jabra 85H with ANC engaged and had similar results in blocking most extraneous sound (my wife's too-loud Real Housewives programs). I don't have any better ANC to test them against, but I'd assume that superior ANC like Bose and Sony might be able to beat them. Very, very solid build, again similar to the PM-3s.
It's not entirely clear to me what the IRIS algorithm is doing but I do have a couple observations from listening for about three weeks:
1) Big, big bump to the lower midrange--around a baritone vocal range sweet spot. Guesstimating I'd say the bump is most prominent around the E-flat below middle C to the B-flat below middle C, so that would be roughly 155 hz to 240 hz. I'd love to see some measurements of what's going on here on the frequency charts. Good bass extension; organ pedals have the gut rumble of a good subwoofer. Due to my age I can't really comment on the higher end since I can't hear anything above 10khz any more. The bump definitely drops off way below that point though.
2) That's not all though, there is definitely some playing around with the phasing. It's more noticeable with larger ensembles (orchestras and choirs). It does have a very pleasing effect, with a more open and natural-sounding soundstage. I'd put these in the "fun" category, not the "neutral" category, definitely.
3) On older stereo like early Beatles, where there is a very hard pan for various instruments (probably as a result of double tracking), with the IRIS algorithm engaged it makes them sound like a single ensemble rather than separate instruments playing off on their own. Again, not neutral or faithful to the original at all, but it sure sounds better to me. I'd assume this is more of the phasing manipulation.
Maybe these observations can give some ideas as to what's going on here.
The IRIS algorithm can be shut off without the app; there's a switch on the right ear cup that you press to turn on and off. I usually use the app to switch the algorithm on and off though. The switch is a little hard to find without practice. Other than the on-off switch, most of the controls are indistinguishable and not user-friendly. They were clearly going the Apple route of pretty over practical.
Other than simplifying the bluetooth connection process, the app isn't necessary for using the headphones. I have had zero problem with bluetooth connection with my older iPhone. Range is excellent and battery performance is as advertised: after three weeks I've only charged them once, when I got them and I have listened to them almost every day for at least an hour and sometimes up to three (they do make one rather sweaty after about the second hour due to the isolation seal).
I like them quite a lot. I wouldn't use them for reviewing CDs because they aren't at all neutral, but for listening enjoyment, they rank pretty high in my book. I've referred to the sound as addictive; it reminds me of the feeling I had when I first used a tube amp, and didn't want to listen to anything else.
Sorry, I know this isn't at all scientific, but these headphones don't seem to be discussed anywhere else on the forum that I could find in a search. If anyone has questions about them, I'll be happy to try to answer.