I too encountered some brightness when i listened to it for the first two to three hours. When I tried my system the following day, I noticed it wasnt there anymore. Consider this as the burn in effect.
Similarly to you
@IanB52 , i too run the EtherRegen before its connected to my TPLink M9 Deco (main mesh - access point). I also have an iFi ZenStream, and when i used the Lan iSilencer on it, it tightened up the sound and I experienced the same effect as you did.
IME - like you said, the best place for it was at the router before the EtherRegen. Widest depth and soundstage, midrange was smooth, warm, very little sibilance to vocals (my pet hate) apart from what was recorded in the song. What this has taught me is that its best to curb noise at the source, and that way everything else connected to the network benefits.