I would certainly recommend that playback is started before you set out on your drive, and that a mount or cradle holds the player. I'd use a media player app that has easy swipe controls to make track changes quickly, I usually use Poweramp in the car, but the recent updates to GoneMAD make it a pretty compelling alternative. Unfortunately neither of them follow the source sample rates (yet). Neutron sounds great, but the UI is a PIA to use while sitting comfortably in the living room, never mind for use in a car. I don't really like the interface of the MangoPlayer app myself.
As far as the audio, did you have a preference between the DX160 or R3?
This is pretty awesome, wish my Regal would do the same!