Yes I also have the QX-5 and AX-5. I am feeding 802D speakers which are not mini by any stretch of the imagination. It is heavenly sounding.
My original demo of QX-5 was with 803D3 where the QX was fed by a Melco server via USB, all Transparent cabling, AX-5 Twenty, and I thought it was one of the best sounding systems ever heard period.
I got a LOT closer to that sound with room treatments (this turned out to be the biggest tweak of all), better Transparent USB cable.
I have a big custom built PC with monster specs for gaming. Not good for audio, theoretically, but it works great. I will eventually, down the road, audition a Melco like device, but honestly there is no need at this stage it just sounds so good. Once I got the room under control, the need to upgrade quieted a bit and I can just enjoy the music. Having said that, at some point I will get bored and at that stage the Melco will get tested. I can't speak to how the Melco compares to the Aurender, but people whose opinions I value have told me that the Melco is the best sounding solution. I would check it out if I were you.
As for USB v. Ethernet, not even recent videos by Charles Hansen himself explaining all about the QX-5's development were enlightening on that point but people I know who have experimented have told me that you really want some device in between your network router and your dAC, and then a really good ethernet cable like a Transparent from that device to the DAC, but it is unclear what exact device one would use. Lots of discussion on the subject on Computeraudiophile.com right now. The computer audio stuff is turning out to be a lot more interesting than I thought.