Yup. this is the setup that also works for me, a Roon Rock in a NUC, a NAS storing the files, tucked away from listening areas, as endpoints, AudioByte HUB, SMS-200 Ultra, Chord 2Go, with a multitude of DACs.I tried most of these combinations. Currently, I separate the Roon core (fanless NUC PC running Linux and Roon Rock software) from the music files (Synology 4-bay NAS), and use various Roon endpoints (such as the Hub) around the house to stream to DACs and speakers. In theory, Roon Nucleus should probably be a better (and neater) solution for the Roon core, but I could not detect the difference in sound compared to my NUC PC housed inside the Acasa fanless case, so I invested more in DACs (Rockna Wavedream, Holo Audio May) and cables. In my experience, NAS performed poorly as a Roon core, a dedicated NUC PC or Roon Nucleus were much better.
The forthcoming Rockna Wavalight Server promises to combine the streamer and Roon core into one unit, but I am curious about the performance and looking forward to tesitng it. When you read Roon white papers, they clearly recommend separating the core from the streamer for best performance, but maybe this advice is outdated.
just to add a bit more gasoline into the fire of the Innuos, Nuc rOck, Roon Nucleus, also check Silent Angel line of music servers and streamers.