Thanks! Wendy Carlos created the original TRON soundtrack from the 1980's. Whether you'll like it or not, you never know until you try.
(I have my guess, but I would not want to implant a bias!)
No idea about market share and availability, however I thought this thread is about audio resolutions. Personally, I would love to see the science of audio updated a bit from down here at the consumer level. I admit I have no idea what is cutting edge acoustical research, so maybe they are already doing this kind of stuff.
Yes, synths as we know them are usually pretty artificial, but what I was inferring from "computational cluster" is a full on simulation of sound. Think of digital effects in movies. Many are pure digital constructs and when successfully done, you won't even know they were there. That visual simulation (rendering) has gotten to the point where they implement both photons AND waves of light. If you can simulate waves of light, you can start thinking about waves of sound, too. Also, the "quality of harmonic nuances" is why the simulation should be carried out to an extreme level of 0 Hz to 384 KHz if possible. I'm guessing that range should encompass just about any harmonic interactions from natural instruments.
Also, my suggestion was a way to remove "what is a good recording?" from the test. Think of the debates that would cause! Theoretically, minor variations in attack/sustain/decay could also be simulated to make the sound more natural. Computational power is probably not the limiting factor for such a project.