I have home premium 32 on my desktop, ultimate 64 on my laptop. Very happy with Vista. No crashes, only a couple of compatibility issues in the beginning which were fairly quickly resolved (got the desktop shortly after Vista was released), none since very early on.
I'm happy with the new Windows Mobile Center, used to sync my PPC.
Use Photoshop, Gmail, IE7 (not happy with it, think I'll check out firefox in a minute), iTunes (prefers 32bit version), Office 2007 (love it), MS Money, Google Earth, Streets & Trips, ...
There was a lot of negative response when it was released, but I haven't had a bad experience. I know people who say they hate it and will never use it. Oddly, they've never tried it. Oh well.
Denise