Mojo would work fine with V281, provided that you ensure that you have set the mojo to line level voltage (e.g. +4 dBu) and don't crank it up.
Mojo does have a "line out" mode by pressing the button combination on startup, but one annoying thing about Chord is that their "line out" voltage is 3Vrms (+11.7dBu), which is quite high compared to other brands, and may make the V281 volume knob feel too sensitive, so you might want to set the rear input gain switch down a bit.
V281 can handle up to +21dBu, so it is one of the most tolerant amps out there for input voltage, but you should still be careful not to accidentally crank up the Mojo and overload the V281 input circuit. Other headphone amps are not as tolerant as V281, so I've seen a few Hugo/Mojo users unknowingly clipping the input stage of some headphone amps, making the amp distort and sound "hot".
Anyhow Mojo doesn't have a dedicated high impedance (e.g. 100 ohm) line output per se, and the 3.5mm jack is not be the best thing around for the sake of crosstalk.
If you have limited budget then I'm sure Mojo will serve well for the time being, but you might eventually want to buy a good dedicated line level DAC. Chord also makes 2Qute for that purpose.