It is right on topic actually, we've all at some point had noise problems to solve. And with my Topping D90 MQA / A90 connected to my Ryzen 3700x/Nvidia 2070 Super via USB I had GPU birdies, but I also had RCA connection and noise problems, which I first solved with better shielded cables for RCA, XLR, and USB. All that was left was GPU induced noise when I ran GPU compute or played games.
Fortunately I didn't have mouse movement induced noise, so for a while I lived without the iDefender+ and as I researched solutions for solving the Gaming / Compute noise from the GPU, I found the iDefender+ was the most affordable option - not as cheap as covering the connector power pins with insulating tape to break the power lines connection at the PC, but the iDefender+ did more intelligent handling of sensing and loading the ground - and was designed to cut out noise from the audible range - so I tried it, and it worked.
I had 2 DAC's hooked up so I needed 2 iDefenders initially, then I used a DK1 dock with split power and data ports for the FiiO M15 and no longer needed the iDefender+ for that USB connection to the PC.
I used the USB-A to USB-A version for the D90 - USB-B to the D90, USB-A to the PC, plug the iDefender+ into the PC and the USB-A from the D90 into the iDefender+.
There isn't anything else to do unless you need 5V power to drive the DAC, then you'd get a low noise 5V power supply to plug into the side of the iDefender+, I used the iPowerX also from iFi initially to power the M15, but then I didn't need it after I powered the M15 through the DK1 dock.
Here is what/where I bought the iDefneder+
https://www.amazon.com/iFi-iDefender-External-Ground-Eliminator/dp/B0849J33T9
Here is a video that shows before / after GPU noise using the
iDefender3.0, the predecessor to the iDefender+:
ifi iDefender 3.0 Review & Demo: Breaking a GPU Noise Ground Loop
I have a Topping HS01 arriving in hopefully a week or so from China - tracking shows it took 4 days to make it from Hifigo to the Airport and fly out - usually it is only 1-2 days. From flight out it usually takes 7-8 days, but that was before the Port/Customs backup's in the US, so it might take a bit longer this time..
I'll swap the HS01 in for the iDefender+ and report back how it works out.