I use them with the Geek Out 450, with high quality files.
People also talk about a boosted bass, I don't hear that to be honest. To my ears, the bass is on the lighter side of neutral.
While I never tried the Geek Out 450, it might be sound signature of it that makes the bass seem on the lighter side and your perception of the upper mids and highs being harsh. Do you have any other amp that you can try with the HD-650? Also is it a new one or used? If used then some have said the pads will change the sound.