Depends on the sound signature your looking for, I have both the HD485 and the SR80.
The HD485 are a tad more comfortable overall, but out of the box they are pretty warm. They do open up a bit after a long burn in period. The downside of the HD485 (well at least for me) after a few months of light use, never abused or mishandled, the headband cracked. It took a month and a half, and several half hour long distance phone calls to receive a replacement from Senheiser. I'm not trying to knock the Senheiser brand, I just wish the repair process was a bit smoother, I would still buy more Senheiser's cans, and still recommend to friends and family.
The SR80 differs from the SR60, by having a bowl shaped pad as opposed to a flat pad. The Grado's are definitely more fun when listening to rock type music, they are less veiled in the mids and highs then the Senheiser's. Some will say they are uncomfortable, but I found washing the earpads a few times with a mild shampoo softened them up significantly.