One thing I've learned about the 650s is that they sound great out of the box, but they can be vastly improved upon. The most obvious first step is a good 100+ hour burn-in.
When I first got my 650s, maybe 18 mos. ago, I listened to them for 4-5 months with a stock cable, and almost a year unamped (in fact, checking my journal I was still using the stockers a year ago). I did listen to them before I burned them in, but I don't remember too much, I think I found them to be a bit cold and distant. After a burn-in, with the stock cable they sounded amazing powered by the headphone out on my Yamaha receiver (which is supprisingly good for such an unassuming piece of equipment.)
I did get some Blue Dragon Mk. IIs in May of last year and did a bit of A/B comparison. Even powered by the Yamaha with a moderate-at-best source (Edirol USB DAC), I found a tangible improvement to the sound, especially in the area of tonality. I didn't get an amp until last September, when I bought a GLite + DPS off eBay (from a fellow head-fier who's fairly local, actually). Certainly that made a world of difference. I've discussed the synergy between the GLite and the 650s before, but the short version is that the Senns gain a great sense of spaciousness from the Gilmore's famous "wall of black" sound.
The most recent upgrade I did was buying an
Adcom CD player, which has
really changed my view of the 650s, though it's taken some time to appreciate the finer aspects of this arrangement.
The two things I have not done with the 650s that I really want to is to run them in balanced mode (the gains of which I read are quite significant), and to hear them with crossfeed. Sounds like there is an expensive Headroom purchase in my future.
The point of this all is that the the HD-650s are quite sensitive headphones, and react quite strongly to whatever is upstream of them. I actually think they are a very good deal in the world of headphones, for two reasons. One, they start out with a good sound, but respond very well to a careful upgrade path. Two, they offer many more listening hours than other cans, in that I never find them to be fatiguing in the slightest. This is in my experience, of course.