It will work, either using the included balanced XLR cable (4.4mm to 2x 3pin XLR) from the front of the Diablo (where you use the diablo as volume, when the speaker are left ‘turned up to a comfortable point(your required max volume with the diablo set to its max non clipping level, as likely indicated in photos below)) or the Diablos’ rear output, which is a balanced ’line output to sources’, such as active speakers which have XLR inputs and are powered- indicated by the word ‘active’ in their label ‘active speakers’. In that situation you use the volume control on the active speakers as the Diablos volume control will not affect the rear (line level) output. Using the Diablo rear output is preferable, but will not work for many users, and hence another method might be required- using the front outputs.. most likely using the cable below.
The other method is to put a 3.5mm to 2x phono plug (RCA connectors), like the laptop cable to analogue sound cable /powered speakers that has typically been used for decades and is for sale in many many places... plugging that cable into the included 3.5mm to 6.3mm adaptor, and then plugging into active speakers RCA/Phono inputs will work as well.

(^^^^^the aforementioned 3.5mm to 2x phono plug cable^^^^^)
If the speakers need a preamp, the Diablo is ‘it’,.. if they want a line level and have their own volume control then you set the Diablo to give ‘line level’ output volume and then adjust volume via the Speakers volume control.
You can give line level output from the Diablo in several ways; using the rear output (requires balanced XLR connection), or using the front outputs, at which point you will need to provide line levels (as likely indicated in the photos below).
Sometimes you have to adjust the Diablo volume up or down in volume to find ‘less humm’ or noise.. but if this is the case; try first moving the cables around (ie away from power cables and wall warts etc) until the noise goes away.. - and of course make sure that the speakers are not set too high /or are the cause..
I gave a post a few pages back showing photos of the Diablo at the various ‘line output volumes’ in its’ different modes..
edit: further back than ‘a few pages’; post #806 (pg54)
(please excuse the ‘thin blue line’ I should have ‘circled with texta’ the appropriate jacks (the jpegging removed much of the ‘arrow’ pointing to which jack was being indicated); but if you look keenly you will see an arrow indicating which jack and which mode to use, and the volume pott indicates roughly where ‘full LINE LEVEL’ output would be found in each config. This should give maximum dynamic range without overpowering the input circuit on the downstream audio kit)
edit: basically the ‘top row/first three’ photos are the SE output (6.3mm), and the ‘last two/bottom row’ shots are using the front ‘balanced’ output jack (4.4mm).
_______________________________________________________________________________________________________________________________________________________
Heres a similar situation (active speakers) using the regular ‘single ended’ headphone out into a Sunfire Subwoofer and then daisy chained onto a Bowers and Wilkins Zeppelin.

In this instance I could set the active sub and active speakers to volume levels that work with each other and then use the Digital Audio Player (DAP)to adjust the volume (with the Diablo set to max/line level output), or leave the DAP to line level output, and use the Diablo to adjust the volume.
If I was to turn the volume up on the Diablo above the ’line level’ photos in the linked post, I would expect distortion in the other kit, due to clipping..
Even with the 2700watt sub running at a low level, I could create distorted sound, easily, if I set the Diablo above ‘line level’ output (which is what the other devices EXPECT to receive)..
This is why using the rear of the Diablo, which IS set ot line level output, is ideal, but requires you buy speakers with XLR inputs. These speakers would be active, and be amplifying the sound, where as the Diablo would be using all of its power to give a nice dynamic ‘line level’ output.
True the Diablo IS an amplifier, and can power small sensitive speaker drivers VERY WELL (ie headphones).
It can be useful to have a strategy with your setup to stop others ‘potentially hurting the equipment’ (clipping distortion isn’t great to amplify)..
So some strategies might include:
A) Setting the Diablo to line level output, either using the rear (where the Diablo volume pot does NOTHING), or the front (setting to a level like the photos above indicate/where their is not sound distortion/clipping) and Hiding the Diablo/putting it out of reach; and tuning your powered speakers to the max volume level you would wish them to give. Then you can use the volume level on your phone/DAP/laptop etc to adjust sound.. this setup works logically as the place where people adjust the songs/tracks is also where the volume can be controlled from- note that this setup isn’t ideal as the dynamic range will be artificially compressed to whatever is output from the source.. The Diablo will have limited magic it can do in this scenario- although it will still make music notes sound realistic etc.. but no one needs to touch ANYTHING ELSE, and this will allow controlling/stopping potential damage situations from happening.
B) Setting the laptop/DAP/Phone to full volume output=>having the Diablo at ’line level’ output=> and adjusting the volume on the (active/powered) speakers... (this is more ideal)
I’d use both setups depending on whose party it is (how technical are the guests and how drunk is someones partner who has a penchant for ramping up ‘cotton eye joe’ to full volume might be).
Many paths to the summit.
I bought the Diablo as a DAC/preamp - the way you wish to use it - AND to drive super sensitive speakers. Some would say I don’t need the Diablos RAW power; but that RAW POWER driving clean line level output and giving exceptional headphone control makes it very ‘high end’ in terms of sound output.
Just know that you CAN drive even old computer speakers expecting a 3.5mm input (ie a 3.5mm to 3.5mm cable, using the Diablos adapter to turn one end to 6.3mm).. (I’d give a photo but this cable is in use on the above setup and is offsite to me presently)
I bet you could find an incredible ‘old school‘ set of computer speakers (with a big ass sub unit) for very little coin.
Sme sets are ‘very high end’ and mixing kit can achieve some great results.. (like my B&W /Sunfire combo shown above; although THAT was for testing purposes to see if I would be happy with the sound as a makeshift music setup)( I WAS ! ) It would be ‘beyond party level sound’ for many people... /adequate.