I had a simliar problem with computer generated noise and everything I found online told me that it was probably a grounding issue inside the computer. In other words, something somewhere was touching something it shouldn't and leaking some current. Apparently it's not exactly the mouse you're hearing, but actually the videocard.
I took the whole computer apart, made sure nothing was touching anywhere, insulated where I thought there might even be a chance of something touching, and . . . it was still there.
Other online posts I found suggested it was RF interference in the case, again originating with the video card.
In the end, I bought a Fubar II USB DAC and not only is the problem gone, the sound quality improved dramatically over my old Audigy2.