I'm fairly new to high-end gear, I just bought a HD800 and Cambridge Audio DACMagic Plus. I have way over 4000 hours on my trusty old HD515, which were "good" for every day use... or at least I thought so until now. I've had the chance to listen to a few high-end reference phones years ago but never paid any attention, they lacked feeling and felt uncomfortable.
Worked in the HD800's for about 24 hours, and I was getting worried that the harshness would make listening a headache... there has been noticeable improvements since first setting them up but I was starting to get buyers remorse... I randomly discovered TwoEars' foobar2000 setup, plus adding a +3db bass boost at 125Hz cross-over via the DACMagic windows driver... simply amazing. Best audio I've ever heard. My jaw is on the floor. The detail and soundstage is simply incredible, and the bass is now responsive and feels powerful and super detailed but not overbearing, and the harshness of the 6k-8k oversensitivity of the HD800's is not at all noticeable any longer.
My opinion as an amateur - this mod dramatically improves the HD800's personality.
EDIT 2015-02-10--------
Ok so now after owning the HD800 for almost 2 months (with daily use 2-8 hours) I have a different opinion. Maybe it is a result of more burn-in and/or getting accustomed to the cans. I personally feel that the dolby headphone DSP component in this configuration severely detracts from the quality of the audio. Also I came to realize that the "base boost" in the drivers don't affect the audio from foobar since obviously WASAPI mode bypasses the operating system mixer (durrr I'm special
).
So now my foobar DSP setup only includes the Electri-Q equalizer with a -2dB reduction around 6kHz and a +3dB boost at 50Hz. Much improved clarity, detail, separation, and staging in comparison to this HD600 DSP config, while maintaining an acceptable level of punch to the bass. The current config isn't as gentle to poor quality mixing in the source audio though. I guess that the HD800s need a lot of burn-in time to start shining.