I notice quite a difference using my HD25-II with a JDSLabs C421amp (with OPA2227 opamp) hooked up by LOD to my iPod, vs. running them off the iPod directly. Yes, the iPod can drive them reasonably well, but they sound a lot better though the amp. The sound is just bigger, less congested, the instruments separate better, the sound is clearer from bottom to top.
Your mileage may vary, but I'm not giving up my C421 anytime soon!
EDIT: I've never tried the E17. I had (still have, but don't use) an iBasso D-Zero and was using it with my iPod (4G Touch) and HD25's before. It made those headphones a bit too forward (even though I love the forward presentation of the hd25's) and fatiguing. The C421/2227 pairs really well in my opinion. It takes a step or two back in terms of forwardness, which reduces fatigue but without sacrificing the liveliness and energy. If you don't think you need the DAC of the E17, if you're wanting it mostly for portable use with your iPhone/iPod, I'd recommend you check out the C421. It's a bit more and lacks the DAC, but you can't use the DAC with your iDevices anyway. And from what I've heard, the MacBooks have decent on-board DAC.