Thanks for the reply !I would say that I2S sounds best but it doesn't mean that non of improvement can be noticed with SPIDIF or AES.
From my experience compering those scenarios:
1. Source > usb > DAC
2. Source > usb > U18> SPIDF Coax > DAC
3. Source > usb > U18> SPIDF Toslink > DAC
4. Source > usb > U18> I2S > DAC
Those are combinations that I've tested. I don't have AES cable to try this solution.
Now, let's say option 1 is 5/10, option 4 10/10, 2 and 3 would be 7/10.
Many say that AES is superior to Coax or Toslink so I my opinion I'll notice major difference using DDC like U18 especially in studio environment where multiple devices are used which may generate a lot of noise. USB isolation is main advantage of those DDCs' .
I am definitely considering the GD as it is superior in sound to U-18, and a guy that owns it just told me that it sounds equally good via AES