@hobieboyca
+1 re
@Highfive99 's masterclock recommendation.
I'd agree USB source is less critical with a DDC in absolute terms, but my experience, though hardly extensive, is everything matters if you're trying to optimize your sound in a revealing system.
My U18 feeding my R26 sounded much better fed by an Ifi Zen Stream than directly by my Mac Mini M1 running Roon/HQP. Currently with my very good but not exotic USB & I2S cables I still prefer the R26 internal NAA streamer/ renderer (+ OCK-1) to even the Zen/U18 (+OCK-1) combo.
Over on the R26 thread there seems to a pattern over time of U18 or DI-20HE fed by really good USB sources (like Jcat XE or Ifi Neo Stream) more consistently being preferred to the R26 internal streamer.