The Simpson's theme sounds amazing on a home theater system. It's Danny Elfvin, no?
Sesame Street: The Toots Thielman harmonica would be enough for this one to rate, but check out Maynard Ferguson's version of it sometime!
Agree with the Flintstones. I once heard a big band do it over rhythm changes. Btw, there's a GREAT cd that has all the music from the series including - the Way-Outs, the Diner-hop Song, Let the Sun Shine In, Soft Soap song, Hoagy Carmichael, "Frederick" singing mock opera after the cactus cooler bottle hits him on the head, and more.
For Gilbert & Sullivan fans: Mr Ed.
Someone mentioned the Beverly Hillbillies. Does the Bel-Arabs count?
And finally one of my all-time favorites. . . The Green Acres theme song. I arranged this for my high school orchestra way back when, but they woudn't do it.