there is no audible change between firewire or USB, both are digital connections between the system and the device
NOW
devices for firewire usually tend to be higher end than devices for USB, due to the technological advantages of firewire (just its design, vs that of USB, suits it for higher quality stuff (like MOTU or PreSonus' gear)), although firewire itself does not make these devices higher end
its like comparing Pierelli tires and Goodyear tires, high end cars, such as a Ferrari, will usually come with Pierelli, this isn't to say that Goodyear wouldn't work, its just that Pierelli is usually whats put on those cards (because of various technological advances, or because its the only tire that fits the car's stock wheels, or whatever the case may be), although the Ferrari isn't powerful and amazing because of the Pierelli tires, its powerful and amazing because its a Ferrari
firewire vs USB tends to pan out like that, USB devices usually include things like small DAC/amp units (like the Firestone FUBAR), granted there are some exceptions, where very high end devices use USB (such as the Grace m902, which is amazing quality)
although if you look at firewire devices, such as the M-Audio Firewire 410, or PreSonus FireStudio, they're going to be higher quality than something like the E-MU 0404 (in terms of features, functionality, for what they're designed to be (recording interfaces), arguing the sound quality/flavor is something entirely different)
so basically, if you're deciding based on the interface, it doesn't really matter, look at other specs on the units instead, as there are a lot of good USB devices (such as the E-MU 0404, or FUBAR, or m902 (all three mentioned here)) and a lot of good firewire devices (such as the Firewire 410 and FireStudio (granted the FireStudio is massive overkill just for listening to 2 channel audio))