I'm quite new so forgive the basic commentary, but I have found the R70x quite comfortable myself. I bought them about a week ago to replace my old ATH-AD700s and have been able to wear them through my entire workday comfortably. The pads were a bit stiff at first, but after a few days they have either softened or I just got used to them. I also wear thick plastic glasses and the R70x are still very comfortable worn over my glasses. I do have fairly average sized ears, so I don't have issues fitting my ears inside the cups like I saw others have. That said, I have ordered the Brainwavz XL Micro-suede pads just to see how they compare.
As for the sound, again I'm not very experienced in describing headphones, but I find it to be excellent. Overall very neutral with a bit of punch on the low end, which is exactly what I was looking for as an upgrade to the AD700. Instrument separation and soundstage are also fantastic. I previously tried the Hifiman Deva out and found the sound very fatiguing and the headband not to be comfortable for long sessions, to the point that I felt a huge relief every time I took them off. On the other hand, I will find any excuse I can get to sit at my desk and put on the R70x. I ended up returning the Deva for the R70x and could not be happier, the sound and comfort were exactly what I was looking for.