I got them about 8 years ago, the cable broke after 3 years but I always had them with me while at school.
Having the option to replace the cable is nice but 20$ seems a little expansive just for a cable.

For the average teenager who don't have a lot of money, this is a great product.
I prefer the sound on these than on the Sennheiser 350SE and they were half the price.
The main disadvantage for me is that the PX22 are wired and that my last similar headset from TurtleBeach broke easily.
I have not used the PX22 much because I prefer other headsets that I have such as Sony Pulse and Logitech G933.

I was quite disappointed by this headset at first.
 
Please note many people recommend using an amp such as the Asus Xonar DG but my onboard audio is just fine, my motherboard is asus p8p67
 
The mic mechanism for muting is useful, it's easy to know if it's muted or not.
 
Noise cancellation works great.
 
When I got these, the Game One and Game Zero did not exist yet.
 
One thing "missing" with this headset when compared to other gaming headsets is that they are stereo (no built-in surround but apparently it can be simulated by software, see SBX Pro studio, Razer VSS)
 
This being said, I feel a little dumb for not realizing it before : you can adjust the volume with the little/subtle rotating button on the right ear !
 
When compared to Sennheiser HD 558, the PC350 has less bass, the soundstage is wider, the voices sound a little "weaker/cheap" but the music/sound is cleaner/clearer.
 
Some cons when compared to Logitech G933 :
- no presets/options for adjusting equalizer
- no wireless
- no surround
- no side-tone (hard to hear yourself when you speak, it takes time to get used to it)
- expansive (I paid 140$ for HD558 and 190$ for PC350)
 
On the plus side :
- premium look & build quality
- no USB required
- it's easy to know when mic is on/off
- good for people who likes it with less bass

I'm not an audiophile but I simply like headphones ...
As a programmer and a gamer, I spend a lot of time using headphones.
I own many such as TurtleBeach PX22, Sennheiser 350SE and Logitech G933.
For the average Joe, I think the Sony Pulse are the best of my 4 headsets, mostly because of the price and the simplicity (no extra soundcard needed)
but also because the sound is really clear and rich.
Sadly, this headset is not better known from audiophiles, I would like to see what others think about this product.