i just have both on my desk, because from anything written i could not decide!
I am still not decided, every time I switch i like them both
HD 600, more highs, less bass, brighter sounding, but i could not say they fatigue my ears.
HD650, less highs, tiny bit more pronounced bass (which I actually like), maybe a little darker sounding but that depends heavily on the tracks. Since I listen to rock/metal a lot, i think i like the 650s more, because some tracks like nothing else matters from metallica just do not sound as good on the HD 600.
The problem is I could find tracks where the 600 win, and I could also find tracks where the 650 win
no fatigue on both however! maybe in very bright mixed tracks the 600 can be a little over the top with highs, but so can the 650s be with very dark mixed tracks.
I will keep listening to both a little while longer before i pull the trigger on sending one of the two back