I think Roger Russell does a good job of summarizing the debate:
http://www.roger-russell.com/wire/wire.htm (this isn't meant to incite an ABX/DBT debate - he covers a lot of history and back and forth from at least the early 1980s; he does have his own bent, but I can't find a more concise article on the topic)
The only thing I'd really worry about in considering boutique wire is causing your amplifier to oscillate, otherwise you're probably looking at a fairly sedate kind of tweak (in that it's unlikely to actually damage anything, whether or not you actually "like" or even notice any sort of changes is more up to you than anything else). I would agree with Lenni regarding system design, in general - if you even want to consider "high end" cables, it should be pretty near the end of the list. Spend the most time/energy/money/etc on the transducers (speakers, subwoofers, headphones, whatever), matching them to a suitable amplifier (both in terms of "it can properly and stably drive them" and, if you're so inclined, "synergy"), appropriate source (and source material), and so on. Then worry about tweaks (if any) - which are basically going to be something you'll have to make your own mind up on, and that includes cables (among other things).