I will let you in on a not so widely know tweak!
Snakeoil Strings!
http://www.sobstrings.net/
This is NO JOKE!
Vintage Formula:
Introduced back in 1989, these are still the only strings that accurately reproduce the original bell-like tone and warm respinse of the pure nickel roundwound strings of the 1950's and 60's. While retaining a contemporary feel, our "Original Nickel" sets are the ultimate experience for players favoring vintage instruments. Being particularly effective for any single-coil instrument, they are useful for the modern player who wants a warmer tone from any guitar.
He also makes a Rock Formula:
Our "Rock" Formula string sets are designed for the modern quitarist who wants maximum output, harmonic response, and ultimate flexibility! These string sets work well on any single-coil or humbucking equipped instrument. Our specially designed nickel-iron alloy combines several other components for extra long life, durability, and low fret-wear.
There is Bass also but have never tried them.
I personally prefer the Vintage which works GREAT on a STRAT. My EJ Strat has never sounded better and I would put this up against any string in the commercial arena.
Sustain is truely unbelievable.
Try these you will not regret it! Best know secret I have ever tried. I found it on a Fender forum and people were raving about them so I tried them and have put no other strings on my guitar since.