Hard to find an everyday audiophile that can really hear the difference in copper cabling to your speakers.
Wire size is really important if your are using longer cables.
Signal rejection can be important if you have a lot of EM radiators in your area. Computer, Television, Wireless, and Telephones come to mind.
I used regular zip wires until I could make my cables, which I did from Cardas Quad Cable, bought in bulk, some gold plated connectors (these are not worth it from my viewpoint now), along with some shrink wrap. To this day, I cannot be sure I can hear a difference in my 12 foot cables. I was using them in a biwire situation using a receiver initially, now they are just single runs with a stereo amp.
The quad wiring is twisted to minimize the crosstalk between straight wires in parallel. This is true of the DIY Cat5 cables, which will be my next project. I also plan to look at some shielded cables, perhaps I can find some shielded Cat5 to work with.
Spend money on the components. Wire is Wire to speakers, in several studies, both scientific and audiophilic. I do think there are wires that might let you "color" the sound to a small degree.