I disagree with the above posts. I haven't owned the total bithead, but I have owned a penguin amplifier (not a cmoy), which is said to compare favorably with headroom's portable offerings. I used it with an ipod via the line out, driving the Shure E4 and the AKG K701, and didn't think it was any better than straight out of the ipod. There were some slight differences, but I wouldn't call it better. I returned it and bought an SR-71. After that experience, I don't think amps in this price range are worth getting. Just what I think. My experience is limited and there are people who would disagree with me.
I used the SR-71 with the E4 and the SA5000 I traded my K701 for, and it did make quite a difference, and a very tangible difference with some music. In the bass lines at the beginning of Miles Davis' A Night in Tunisia, for instance, I can tell you exactly what details I could hear with the SR-71 that I can't hear without it.
I think you would be better off with the SR-71. If your Macbook doesn't have a decent soundcard, buy a $50 usb soundcard. It will be comparable to the DAC in the total bithead, and the two will make a much better setup. I don't know if macbooks have a slot for this type of soundcard, but I'm currently using a Creative Audigy 2 ZS Notebook soundcard, which runs about $100, and one look at the specs will tell you that it's much better than what's in the total bithead. It doesn't take up any extra space, it's very convenient, and it sounds good for the money. I can tell you from personal experience that it's a MUCH better source than the iPod.