I have tried this using Neutron, but I get much better results with the C5 in line. I'm not sure if it's my particular set of Mobius or not, everyone describes them as treble forward but mine seem excessively harsh on their own. When I initially got them I was getting sibilance on instruments which to me means there is something off. Plus some tracks sounded like they were recorded in a porcelain urn, which they never had before. These effects lessened as I wore the headphones in but they are still there and the sound signature isn't as pleasurable as it should be, and often distracting. I would fiddle with the treble in Neutron on every other track, I use the music setting on the headphones themselves which has a lower treble than flat. The warm setting used to be ok but now they have changed it and cut off way more treble than I like. I had settled on cutting everything above 700Hz by 2db, but even that wasn't completely satisfactory. The C5 cleans up all the above issues perfectly. I also had been having trouble tuning in a satisfying upper sub bass boost. I had a shelf from 90Hz down, but that left out the bass guitar/synth notes so a lot of the oomph and warmth was missing. I dialed in a bump that filled it out, but ultimately it wasn't as good as what the Cayin C5 provides (albeit with some manual EQ tweaks to remove some of muddiness that the C5's bass boost has) So it seems to me that whilst none of these are perfect on their own, together, with some tweaking they can be tuned to audio bliss. But I do have to be careful between songs and ride the pre-amp. After about an hour and a half of use I do think I hear slight clicks on peaks where there weren't before, even at levels that were previously safe, so I do get a bit worried. Usually it is the phone volume that controls whether it clicks or not, I keep the C5 at around 80% and the headphones maxed, with the phone at about 45-46 out of 75 (works out at 61.3 out of 100). According the the Audeze lab, the Mobius input can handle 2VRMS sustained without damaging the DSP. I was waiting for the new update from Audeze, then make a recording of what I hear from the USB port, and then from my setup and see what their representatives think. Maybe the amp in my headset isn't driving the cups properly without additional power?