Apologies for thread necro, but like to add a couple of points.
The LS50 definitely needs a fast sub, so I would definitely suggest a sealed sub, though I've heard reports of good matching with REL subwoofers, which always tended to be a bit more musical. I'm using a Velodyne 12" SPL-1200 Ultra with my LS50s and have the KEFs crossed over at 80Hz and it integrates quite well, though the Velodyne does lag a smidgen. I think the 10" might be better due to the smaller driver, without really sacrificing that much on the low end. The interesting thing is that I've found the LS50s improved in sound when removing the low bass load on them. It seems to play a touch cleaner in the upper mids. If I was in Europe I'd look at the B&W ASW610 as a minimum in a smaller room as it is also quite musical, but doesn't offer much extension in the lows. The REL T7 would probably be be ideal. I have dual SVS SB-13 Ultras on my radar for the future.